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1166827-44-6

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1166827-44-6 Structure

1166827-44-6 Structure
IdentificationBack Directory
[Name]

AZD-7687
[CAS]

1166827-44-6
[Synonyms]

AZD7687
AZD-7687
AZD 7687
[trans-4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid
Cyclohexaneacetic acid, 4-[4-[6-(aminocarbonyl)-3,5-dimethyl-2-pyrazinyl]phenyl]-, trans-
[Molecular Formula]

C21H25N3O3
[MDL Number]

MFCD23098776
[MOL File]

1166827-44-6.mol
[Molecular Weight]

367.44
Chemical PropertiesBack Directory
[Boiling point ]

527.5±50.0 °C(Predicted)
[density ]

1.201±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

4.72±0.10(Predicted)
[color ]

Off-white to pink
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
Hazard InformationBack Directory
[Uses]

AZD7687 is a novel, potent, selective and reversible inhibitor of diglyceride acyltransferase-1 (DGAT-1).
[in vivo]

Prolonged pharmacological inhibition of DGAT1 with AZD7687 in mice results in the same skin phenotype, including sebaceous gland atrophy and alopecia, as seen in the skin of DGAT1-/- mice. AZD7687-mediated effects on the skin were dose- and time-dependent and reversible[3].
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