| Identification | Back Directory | [Name]
Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[1-(1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)-3-(2-thienyl)-1H-pyrazol-5-yl]- | [CAS]
1170387-92-4 | [Synonyms]
Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[1-(1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)-3-(2-thienyl)-1H-pyrazol-5-yl]- | [Molecular Formula]
C24H22ClN5O2S | [MOL File]
1170387-92-4.mol | [Molecular Weight]
479.98 |
| Hazard Information | Back Directory | [Uses]
CFTR corrector 15 (Compound 4172) is a corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that repairs the F508del-CFTR folding defect when used with VX-809 (HY-13262). CFTR corrector 15 can be used in research of cystic fibrosis disease[1]. | [References]
[1] Vaccarin C, et al., Synthesis and Biological Evaluation of Pyrazole-Pyrimidones as a New Class of Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). J Med Chem. 2024 Aug 22;67(16):13891-13908. DOI:10.1021/acs.jmedchem.4c00685 |
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