| Identification | Back Directory | [Name]
NS-3-008（HCl） | [CAS]
1172854-54-4 | [Synonyms]
NS-3-008
NS-3-008（HCl）
NS-3-008 hydrochloride
1-Benzyl-3-hexylguanidine hydrochloride
Guanidine,N-hexyl-N'-(phenylmethyl)-,hydrochloride(1:1)
renal,inhibit,Ccl2,NS3008 hydrochloride,Hsd17b4,Stat5,transcriptional,Inhibitor,dysfunction,ameliorate,CKD,NS 3 008 hydrochloride,p65,G0s2 | [Molecular Formula]
C14H24ClN3 | [MDL Number]
MFCD03931143 | [MOL File]
1172854-54-4.mol | [Molecular Weight]
269.82 |
| Hazard Information | Back Directory | [Uses]
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease[1]. | [in vivo]
NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008[1]. | [References]
[1] Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273. DOI:10.1016/j.ebiom.2016.10.008 |
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| Company Name: |
Rhawn Reagent
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400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
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