| Identification | Back Directory | [Name]
(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 | [CAS]
1174038-86-8 | [Synonyms]
Retagliptin Hydrochloride
(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 | [Molecular Formula]
C19H19ClF6N4O3 | [MDL Number]
MFCD22200238 | [MOL File]
1174038-86-8.mol | [Molecular Weight]
500.823 |
| Hazard Information | Back Directory | [Uses]
Retagliptin (SP2086) hydrochloride is a potent inhibitor of beta-amino acids and dipeptidyl peptidase-4 (DPP-4). Retagliptin (SP2086) hydrochloride inhibits type 2 diabetes and improves glycemic control by prolonging the action of intestinal hormones such as glucagon-like peptide-1 (GLP-1)[1]. | [References]
[1] Kim GH, et al. Enzymatic synthesis of sitagliptin intermediate using a novel ω-transaminase. Enzyme Microb Technol. 2019 Jan;120:52-60. DOI:10.1016/j.enzmictec.2018.10.003 |
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