| Identification | Back Directory | [Name]
ONO 1603 | [CAS]
117427-00-6 | [Synonyms]
ONO 1603
1-Pyrrolidinebutanamide, N-[(4-chlorophenyl)methyl]-2-formyl-γ-oxo-, (2S)-
N-[(4-chlorophenyl)methyl]-4-[(2S)-2-formylpyrrolidin-1-yl]-4-oxobutanamide | [Molecular Formula]
C16H19ClN2O3 | [MDL Number]
MFCD02183795 | [MOL File]
117427-00-6.mol | [Molecular Weight]
322.79 |
| Hazard Information | Back Directory | [Uses]
ONO 1603, a novel prolyl endopeptidase inhibitor investigated as a potential antidementia drug, demonstrated neuroprotective and neurotrophic effects in cerebellar granule cells similar to tetrahydroaminoacridine (THA). At a concentration of 0.03 microM, ONO 1603 promoted neuronal survival, enhanced neurite outgrowth, increased m3-muscarinic acetylcholine receptor (mAChR) mRNA levels, and stimulated mAChR-mediated signaling pathways. These findings suggest that ONO 1603 shares pharmacological similarities with THA, indicating its potential as a therapeutic agent for Alzheimer's disease by enhancing cholinergic neurotransmission and neuronal function[1]. | [References]
[1] ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons DOI:10.1016/0304-3940(96)12912-8 |
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