118-04-7

85-54-1

118-04-7

A. To a reaction vessel was added 0.23 mol of 2-(4-chloro-3-nitrobenzoyl)benzoic acid, 300 mL of a 35% by mass sodium nitrate solution and 500 mL of a 24% by mass potassium carbonate solution. The temperature of the solution was raised to 60 °C, followed by the addition of 1.31 g of chlorobenzoic acid solution, 0.311 g of cuprous chloride and 0.211 g of potassium iodide. The stirring speed was controlled to 160 rpm and the temperature of the solution was raised to 70 °C and refluxed for 3 hours. B. The reaction solution was cooled to 20 °C and filtered. The filter cake was washed with sodium bisulfite solution with a mass fraction of 52%, then the temperature of the washed solution was raised to 50 °C, 300 mL of ammonium chloride solution with a mass fraction of 37% was added, and stirred for 90 minutes. C. The solution was cooled to 10 °C and filtered by pumping. The filter cake was washed with potassium bromide solution and subsequently dehydrated with anhydrous magnesium sulfate as dehydrating agent to finally obtain 2-(3-amino-4-chlorobenzoyl)benzoic acid (60.30 g, 95% yield).