| Identification | Back Directory | [Name]
(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid | [CAS]
1180676-32-7 | [Synonyms]
PS 48
CS-1466
PS 48;PS-48
1180676-32-7
PS-48;PS 48;PS48
5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid
(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid
(Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid
2-Pentenoic acid, 5-(4-chlorophenyl)-3-phenyl-, (2Z)- | [Molecular Formula]
C17H15ClO2 | [MDL Number]
MFCD17215962 | [MOL File]
1180676-32-7.mol | [Molecular Weight]
286.75 |
| Chemical Properties | Back Directory | [Melting point ]
114-115℃ | [Boiling point ]
444.1±24.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >20mg/mL | [form ]
powder | [pka]
4.55±0.10(Predicted) | [color ]
white to off-white | [InChI]
1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12- | [InChIKey]
LLJYFDRQFPQGNY-QINSGFPZSA-N | [SMILES]
OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2 |
| Hazard Information | Back Directory | [Uses]
PS 48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator. | [Biochem/physiol Actions]
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site. |
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