| Identification | Back Directory | [Name]
2-Pentenoic acid, 5-(4-chlorophenyl)-3-phenyl-, (2E)- | [CAS]
1180676-33-8 | [Synonyms]
PS47
PS47;PS 47
(E)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid
2-Pentenoic acid, 5-(4-chlorophenyl)-3-phenyl-, (2E)-
PS47,control,inhibit,Inhibitor,PS48,PDK-1,negative,E-isomer | [Molecular Formula]
C17H15ClO2 | [MDL Number]
MFCD18804142 | [MOL File]
1180676-33-8.mol | [Molecular Weight]
286.75 |
| Chemical Properties | Back Directory | [Melting point ]
117-118 °C | [Boiling point ]
444.1±24.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (348.74 mM; Need ultrasonic) | [form ]
Solid | [pka]
4.55±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48[1][2]. | [storage]
Store at -20°C | [References]
[1] Hindie V, et, al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64. DOI:10.1038/nchembio.208
[2] Pastor-Flores D, et, al. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 2013 Oct 18;8(10):2283-92. DOI:10.1021/cb400452z |
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