| Identification | Back Directory | [Name]
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide | [CAS]
118290-26-9 | [Synonyms]
AF-DX 384 Free Base
AF-DX-384; AF-DX384
N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo- | [Molecular Formula]
C27H38N6O2 | [MDL Number]
MFCD00884624 | [MOL File]
118290-26-9.mol | [Molecular Weight]
478.63 |
| Chemical Properties | Back Directory | [Boiling point ]
618.4±55.0 °C(Predicted) | [density ]
1.144±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble10mg/mL, clear (warmed) | [form ]
powder | [pka]
11.55±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively). It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 μM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg. It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine . | [Uses]
AF-DX 384 is a potent mAChR M2/mAChR M4??selective antagonist. | [Definition]
ChEBI: N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide is a benzodiazepine. | [storage]
Store at RT | [References]
[1] F D?RJE. Antagonist binding profiles of five cloned human muscarinic receptor subtypes.[J]. Journal of Pharmacology and Experimental Therapeutics, 1991, 256 2: 727-733.
[2] M.G VANNUCCHI. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats[J]. Neuroscience, 1997, 79 3: Pages 837-846. DOI: 10.1016/s0306-4522(97)00091-2 |
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Merck KGaA
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