| Identification | Back Directory | [Name]
Ro 4 hydrochloride | [CAS]
927887-18-1 | [Synonyms]
Ro 4 hydrochloride
AF-353 hydrochloride
5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride | [Molecular Formula]
C14H18ClIN4O2 | [MDL Number]
MFCD18917216 | [MOL File]
927887-18-1.mol | [Molecular Weight]
436.676 |
| Hazard Information | Back Directory | [Uses]
AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2]. | [storage]
-20°C | [References]
[1] Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. DOI:10.1111/j.1476-5381.2010.00796.x
[2] Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414. DOI:10.1111/j.1464-410X.2012.11189.x |
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| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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