| Identification | Back Directory | [Name]
5,8-Dideazapteroylornithine | [CAS]
118675-83-5 | [Synonyms]
DDPO
8-Dideazapteroylornithine
5,8-Dideazapteroylornithine
L-Ornithine, N2-[4-[[(2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl]amino]benzoyl]- (9CI) | [Molecular Formula]
C21H24N6O4 | [MOL File]
118675-83-5.mol | [Molecular Weight]
424.45 |
| Hazard Information | Back Directory | [Description]
DDPO is a folypolyglutamate synthetase antagonist. | [Uses]
DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 μM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 μM[1]. | [References]
[1] Rosowsky A, et al., Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain. |
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