| Identification | More | [Name]
(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline | [CAS]
118864-75-8 | [Synonyms]
(1S)-1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE
(S)-1,2,3,4-TETRAHYDRO-1-PHENYLISOQUINOLINE
(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Solifenacin(YM905) intermediate 10
(1S)-1,2,3,4-Tetrahydro-1-(phenyl-d5)isoquinoline
(S)-1-(Phenyl-d5)-1,2,3,4-tetrahydroisoquinoline
(S)-1-1-Phenyl-1,2,3,4-Tetrahy
(S)-1-PHENYL-1,2,3,4-TRTROHYDROISOQUINOLINE | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C15H15N | [MDL Number]
MFCD08692036 | [Molecular Weight]
209.29 | [MOL File]
118864-75-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
80-82°C | [Boiling point ]
338°C | [density ]
1.065 | [Fp ]
167°C | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.91±0.40(Predicted) | [color ]
White to Off-White | [Usage]
Labelled Solifenacin intermediate | [InChI]
InChI=1S/C15H15N/c1-2-7-13(8-3-1)15-14-9-5-4-6-12(14)10-11-16-15/h1-9,15-16H,10-11H2/t15-/m0/s1 | [InChIKey]
PRTRSEDVLBBFJZ-HNNXBMFYSA-N | [SMILES]
[C@H]1(C2=CC=CC=C2)C2=C(C=CC=C2)CCN1 | [CAS DataBase Reference]
118864-75-8(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Preparation]
To a solution of 1726 mg (11.5 mmol, 1 equivalent) of L-tartaric acid and 10 mL of methanol, 10 mL of a methanol solution containing 2750 mg (chemical purity 87.4% by mass, 11.5 mmol) of racemic 1-phenyl-1,2,3,4-tetrahydroisoquinoline (racemic raw material) was added dropwise. The solution was cooled to 5 °C, and crystals precipitated. The mixture was stirred for 1 hour, and then filtered under reduced pressure to remove the precipitated crystals of the (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline/L-tartaric acid salt (R-type tartrate crystals). The optical purity of the (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline S-type raw material in the resulting mother liquor was determined to be 83% ee. 20 mL of water was added, and methanol was removed by reduced pressure distillation. A 30% by mass sodium hydroxide aqueous solution was added to the resulting solution (19.65 g) until the pH reached 12, and crystals precipitated. Cool to 5°C, stir for 30 minutes, then filter the crystals under reduced pressure, wash with 20 mL of water, and dry under vacuum to obtain white crystals of (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline (S-type raw material) (1092 mg, chemical purity 93% by mass, 4.83 mmol, yield 42 mol%, optical purity 82% ee). |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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