| Identification | Back Directory | [Name]
5-fluoro-1H-pyrimidine-2,4-dione | [CAS]
1189423-58-2 | [Synonyms]
[13C,15N2]-5-Fluorouracil | [Molecular Formula]
C4H3FN2O2 | [MDL Number]
MFCD09840633 | [MOL File]
1189423-58-2.mol | [Molecular Weight]
130.077 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: slightly soluble; Methanol: slightly soluble | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. | [Uses]
Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis. | [storage]
Store at -20°C | [References]
[1] DANIEL B. LONGLEY Patrick G J D Paul Harkin. 5-Fluorouracil: mechanisms of action and clinical strategies[J]. Nature Reviews Cancer, 2003, 3 5: 330-338. DOI: 10.1038/nrc1074
[2] TETSUYA TAMATANI. Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells.[J]. International journal of oncology, 2012, 41 3: 1148-1156. DOI: 10.3892/ijo.2012.1544 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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