| Identification | More | [Name]
1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole | [CAS]
119006-77-8 | [Synonyms]
1-[(2-fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1h-imidazole
FLUTRIMAZOLE
1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1h-imidazol
1-(o-fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole
flutrimazol
FLUTRIMAZOLC
(RS)-1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole | [Molecular Formula]
C22H16F2N2 | [MDL Number]
MFCD00865591 | [Molecular Weight]
346.37 | [MOL File]
119006-77-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder. | [Melting point ]
161-166℃ | [Boiling point ]
457.1±40.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Practically insoluble in water, freely soluble in tetrahydrofuran, soluble in methanol. | [form ]
neat | [pka]
6.03±0.34(Predicted) | [color ]
White to Pale Yellow | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H | [InChIKey]
QHMWCHQXCUNUAK-UHFFFAOYSA-N | [SMILES]
C1N(C(C2=CC=CC=C2F)(C2=CC=C(F)C=C2)C2=CC=CC=C2)C=CN=1 | [Uses]
Antifungal | [CAS DataBase Reference]
119006-77-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [HS Code ]
2933299090 | [Toxicity]
LD50 in male, female mice, male, female rats (mg/kg): >1000, >1000, 808, 1214 orally; >2000, >2000, 1079, 1446 i.p. (Vericat) |
| Hazard Information | Back Directory | [Description]
Flutrimazole, a novel imidazole antifungal launched in Spain, is indicated for mycosis of the skin. Flutrimazole displays potent broad-spectrum of
activity against dematophytes, filamentous fungi and yeasts, saprophytic and
pathogenic to animals and humans. Similar to other imidazole and triazole antifungals,
flutrimazole exerts its biological function through inhibition of fungal lanosterol 14a-demethylase. Excellent local and systemic tolerance of flutrimazole in patients has been reported. | [Chemical Properties]
White or almost white powder. | [Originator]
Uriach (Spain) | [Definition]
ChEBI: An imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes,
filamentous fungi and yeasts. | [Brand name]
Micetal | [Synthesis]
The antifungal agent flutrimazole was produced from o-fluorobenzoyl chloride and benzene via the pay- gram reaction, the Grignard reaction with p-bromofluorobenzene, the sulfonation with methanesulfonyl chloride, and finally the substitution with imidazol |
|
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
| Company Name: |
Baynoe Chem Co.,LTD
|
| Telephone: |
+86-021-34783353 15000719740 |
| Website: |
http://www.baynoe.com |
|