| Identification | Back Directory | [Name]
(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron | [CAS]
1193447-34-5 | [Synonyms]
CRANAD 2
(T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron | [Molecular Formula]
C23H25BF2N2O2 | [MDL Number]
MFCD25563253 | [MOL File]
1193447-34-5.mol | [Molecular Weight]
410.265 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble0.2mg/mL, clear (warmed) | [form ]
powder | [color ]
dark blue to black | [InChI]
1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+ | [InChIKey]
PVXQJYXODFZTBR-KAVGSWPWSA-N | [SMILES]
[B-]1([O+]=C(C=C(O1)\C=C\c3ccc(cc3)N(C)C)\C=C\c2ccc(cc2)N(C)C)(F)F |
| Hazard Information | Back Directory | [Uses]
CRANAD 2 is a near-infrared probe that binds to Aβ40 aggregates and elicits an emission blue shift. It was shown to bind to plaques in APP-PS1 transgenic mice, in vitro. | [Biological Activity]
CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregatesCRANAD 2 exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD 2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice. | [storage]
Store at -20°C |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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