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1196070-26-4

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1196070-26-4 Structure

1196070-26-4 Structure
IdentificationBack Directory
[Name]

GSK2190915 (sodiuM salt)
[CAS]

1196070-26-4
[Synonyms]

GSK-2190915A
AM-803 sodium)
Fiboflapon sodium
GSK2190915 Sodium
GSK2190915 (sodiuM salt)
GSK2190915 sodium (GSK-2190915A
FIBOFLAPON SODIUM;FIBOFLAPON SODIUM
[Molecular Formula]

C38H44N3NaO4S
[MOL File]

1196070-26-4.mol
[Molecular Weight]

661.84
Chemical PropertiesBack Directory
[form ]

Powder
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Fiboflapon sodium (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood[1].
[IC 50]

LTB4: 76 nM (IC50)
[References]

[1] Stock NS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. J Med Chem. 2011 Dec 8;54(23):8013-29. DOI:10.1021/jm2008369
[2] Lorrain DS, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8. DOI:10.1016/j.ejphar.2010.05.003
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