| Identification | Back Directory | [Name]
BICAPPA | [CAS]
119662-55-4 | [Synonyms]
BiCAPPA >=97% (HPLC), solid
1,4-Piperazinedipropanamine, N1,N4-bis(6-chloro-2-methoxy-9-acridinyl)-
6-chloro-N-[3-[4-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]piperazin-1-yl]propyl]-2-methoxyacridin-9-amine | [Molecular Formula]
C38H40Cl2N6O2 | [MDL Number]
MFCD07370130 | [MOL File]
119662-55-4.mol | [Molecular Weight]
683.67 |
| Hazard Information | Back Directory | [Uses]
BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2]. | [References]
[1] Uliassi E, et, al. 10-Medicinal Chemistry of Hybrids for Neurodegenerative Diseases. Design of Hybrid Molecules for Drug Development. 2017, Pages 259-277.
[2] Bongarzone S, et, al. Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. J Med Chem. 2010 Nov 25;53(22):8197-201. DOI:10.1021/jm100882t |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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