| Identification | Back Directory | [Name]
6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID | [CAS]
1197-10-0 | [Synonyms]
6-(Hydroxymethyl)picolinicaci
6-(hydroxymethyl)picolinic acid
6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID
2-Pyridinecarboxylic acid, 6-(hydroxymethyl)-
6-(Hydroxymethyl)pyridine-2-carboxylic acid 95+%
2-Carboxy-6-(hydroxymethyl)pyridine, 6-(Hydroxymethyl)picolinic acid | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C7H7NO3 | [MDL Number]
MFCD09032021 | [MOL File]
1197-10-0.mol | [Molecular Weight]
153.14 |
| Chemical Properties | Back Directory | [Melting point ]
137 °C | [Boiling point ]
381.2±32.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
0.96±0.50(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 6-carboxypyridine-2-methanol from ethyl 6-hydroxymethylpyridine-2-carboxylate: ethyl 6-hydroxymethylpyridine-2-carboxylate (200 mg, 1.1 mmol) was dissolved in methanol (1 mL). Subsequently, 2 N NaOH aqueous solution (1 mL) was added slowly and the reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction mixture was acidified to pH=3 with 2 N HCl. The solvent was removed by concentration under reduced pressure, and the residue was dissolved in methanol and filtered. The filtrate was concentrated under reduced pressure to give 6-carboxypyridine-2-methanol (150 mg, 89% yield, white solid).1H NMR (400 MHz, CD3OD) δ: 5.05 (s, 2H), 8.34 (d, J=8.0 Hz, 1H), 8.47 (d, J=8.0 Hz, 1H), 8.73 (d, J=8.0 Hz, 1H). | [References]
[1] Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1994, vol. 49, # 8, p. 1127 - 1136
[2] Patent: WO2004/113281, 2004, A1. Location in patent: Page 57
[3] Journal of the American Chemical Society, 1982, vol. 104, # 8, p. 2251 - 2257 |
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