| Identification | More | [Name]
Diethyl 2,6-pyridinedicarboxylate | [CAS]
15658-60-3 | [Synonyms]
2,6-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
DIETHYL 2,6-PYRIDINEDICARBOXYLATE
DIETHYL DIPICOLINATE
DIPICOLINIC ACID DIETHYL ESTER
RARECHEM AL BI 0203
Pyridinedicarboxylicaciddiethylester
diethyl pyridine-2,6-dicarboxylate
PYRIDINE-2,6-DICARBOXYLIC ACID DIETHYL ESTER
2,6-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 98+%
2,6-Pyridinedicarboxylic acid diethyl ester ,99% | [Molecular Formula]
C11H13NO4 | [MDL Number]
MFCD00033792 | [Molecular Weight]
223.23 | [MOL File]
15658-60-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
44°C | [Boiling point ]
188 °C / 12mmHg | [density ]
1.165±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
-0.20±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [Detection Methods]
GC,T,NMR | [CAS DataBase Reference]
15658-60-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow to red crystalline powder | [Synthesis]
Pyridine-2,6-dicarboxylic acid (10.0g, 59.9mmol) was added into ethanol (120mL),
then 3 drops of concentrated sulfuric acid were added. The mixture was heated to
reflux for 8 hours. After evaporation of the solvent, the solid residue was washed with
saturated Na2CO3 aqueous solution and extracted with chloroform for 3 times. The
organic phase was dried with small amount of MgSO4. The solvent was removed to
afford 1 as white powder (12.6g, 56.3mmol, yield = 94%). 1
H-NMR (400MHz,
CDCl3) |? ppm 8.29 (d, J = 7.80 Hz, 2H), 8.01 (t, J = 7.80, 7.80 Hz, 1H), 4.50 (q, J =
7.12, 7.12, 7.12 Hz, 2H), 1.47 (t, J = 7.13, 7.13 Hz, 3H). 13C-NMR (100 MHz, CDCl3)
|? ppm 164.6, 148.6, 138.2,127.8, 62.3,14.2,14.2. ESI MS: m/z = 224.1 [M+H]+
, 246.1
[M+Na]+
.
 | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 9, p. 2599 - 2603
[2] Chemical Communications, 2008, # 21, p. 2444 - 2446
[3] Tetrahedron Letters, 2017, vol. 58, # 10, p. 991 - 994
[4] Molecular Crystals and Liquid Crystals, 2007, vol. 470, # 1, p. 369 - 381
[5] Organometallics, 2015, vol. 34, # 7, p. 1170 - 1176 |
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