| Identification | Back Directory | [Name]
TM2-115 | [CAS]
1197196-47-6 | [Synonyms]
TM2-115
4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-7-(phenylmethoxy)- | [Molecular Formula]
C28H38N6O2 | [MDL Number]
MFCD27963848 | [MOL File]
1197196-47-6.mol | [Molecular Weight]
490.64 |
| Chemical Properties | Back Directory | [Boiling point ]
662.3±65.0 °C(Predicted) | [density ]
1.188±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/ml | [form ]
Solid | [pka]
9.34±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death[1]. | [References]
[1] Malmquist NA, et al. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. DOI:10.1073/pnas.1205414109 |
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