| Identification | Back Directory | [Name]
UNC 0224 | [CAS]
1197196-48-7 | [Synonyms]
CS-1635
UNC 0224
UNC-0224; UNC0224; UNC 0224
N-Debenzyl-N-Methyl-O-deMethyl-O-(3-diMethylaMinopropyl)-BIX 01294
7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
4-QuinazolinaMine, 7-[3-(diMethylaMino)propoxy]-2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6-Methoxy-N-(1-Methyl-4-piperidinyl)- | [Molecular Formula]
C26H43N7O2 | [MDL Number]
MFCD18251564 | [MOL File]
1197196-48-7.mol | [Molecular Weight]
485.67 |
| Chemical Properties | Back Directory | [Boiling point ]
641.0±65.0 °C(Predicted) | [density ]
1.141±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO | [form ]
Powder | [pka]
9.34±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX-01294, is selective G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor. | [IC 50]
EHMT1/GLP/KMT1D: 20-58 nM (IC50); G9a: 15 nM (IC50); G9a: 2.6 nM (Ki); G9a: 23 nM (Kd) | [storage]
Store at 4°C |
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