| Identification | Back Directory | [Name]
UNC2541 | [CAS]
1612782-86-1 | [Synonyms]
UNC2541
UNC2541; UNC-2541; UNC 2541;
2,9,16,18,21-Pentaazabicyclo[15.3.1]heneicosa-1(21),17,19-triene-20-carboxamide, 7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-, (7S)- | [Molecular Formula]
C24H34FN7O2 | [MOL File]
1612782-86-1.mol | [Molecular Weight]
471.57 |
| Chemical Properties | Back Directory | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:10.0(Max Conc. mg/mL);21.21(Max Conc. mM) | [form ]
Solid | [pka]
9.48±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Macrocyclic effect on inhibitory activity a modeling study on mertk inhibitors.MerTK-specific inhibitor. | [in vivo]
UNC2541 (25 μM; pretreatment around the sciatic nerve half an hour in advance) significantly abolishes the analgesic effect of ozone in CCI mice[2].
| Animal Model: | Adult male SPF-grade ICR mice and C57BL/6 mice, weighing 20-22g and aged 6-8 weeks (anesthetized with sodium pentobarbital and sciatic nerve was ligatured by 4-0 chromic gut sutures to establish Chronic constriction injury (CCI) model)[2] | | Dosage: | 25 μM | | Administration: | Pretreatment around the sciatic nerve half an hour in advance. | | Result: | Significantly abolished the analgesic effect of ozone in CCI mice. |
| [IC 50]
Mer | [storage]
Store at -20°C |
|
|