| Chemical Properties | Back Directory | [Boiling point ]
582.6±60.0 °C(Predicted) | [density ]
1.232±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.84±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MS0124 is a Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. MS0124 was 34-fold more selective for GLP (IC50 =_x000D_
13 ± 4 nM) over G9a (IC50 = 440 ± 63 nM). G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates | [Uses]
MS0124 is a potent selective G9a-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM for GLP and G9a,respectively[1]. | [References]
[1] Yan Xiong, et al. Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorg Med Chem DOI:10.1016/j.bmc.2017.06.021 |
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