| Identification | Back Directory | [Name]
CRF (6-33) (HUMAN, RAT) | [CAS]
120066-38-8 | [Synonyms]
CRF (6-33)
CRF(6-33)(human)
CRF (6-33) (HUMAN, RAT)
6-33-Corticotropin-releasing factor (human) (9CI)
CORTICOTROPIN RELEASING FACTOR FRAGMENT 6-33, HUMA
CORTICOTROPIN-RELEASING FACTOR (6-33) (HUMAN, RAT)
CORTICOTROPIN RELEASING FACTOR FRAGMENT 6-33, HUMAN, RAT
Corticotropin Releasing Factor Fragment 6-33 human, rat >=97% (HPLC)
ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER
H-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-OH
CRF (6-33) (human, rat) H-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-OH | [Molecular Formula]
C141H231N41O43S | [MDL Number]
MFCD00671436 | [MOL File]
120066-38-8.mol | [Molecular Weight]
3220.66 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [InChIKey]
XHHPINGDTRCKNN-QZXFXOMNSA-N |
| Hazard Information | Back Directory | [Uses]
CRF(6-33)(human) is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) has anti-obesity effect[1][2]. | [Biochem/physiol Actions]
CRF fragment that binds with high affinity to the CRF binding protein (CRF-BP) but has low affinity for the CRF receptor. Displaces CRF from CRF-BP. | [References]
[1] S C Heinrichs, et al. Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav Brain Res. 2001 Jul;122(1):43-50. DOI:10.1016/s0166-4328(01)00174-7
[2] S C Heinrichs, et al. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav. 2001 Sep 1-15;74(1-2):5-13. DOI:10.1016/s0031-9384(01)00421-8 |
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Sigma-Aldrich
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Energy Chemical
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www.energy-chemical.com |
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