| Identification | Back Directory | [Name]
CAY10614 | [CAS]
1202208-36-3 | [Synonyms]
CAY10614
CAY10614 Exclusive
cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium:iodide
N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide | [Molecular Formula]
C42H78INO2 | [MDL Number]
MFCD18382116 | [MOL File]
1202208-36-3.mol | [Molecular Weight]
756 |
| Hazard Information | Back Directory | [Description]
Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.1 It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.1 | [Uses]
CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model[1][2]. | [in vivo]
CAY10614 (compound 7) (10 mg/kg; i.p. 30 min before the LPS) significantly improves survival of mice given intraperitoneal LPS (20 mg/kg)[1].
| Animal Model: | C57BL/6J male mice (9 weeks) were i.p. injected with 20 mg/kg LPS[1] | | Dosage: | 10 mg/kg | | Administration: | I.p. 30 min before the LPS | | Result: | Increased the survival rate of mice from 0% to 67%. |
| [IC 50]
TLR4: 1.675 μM (IC50, in HEK293 cells) | [storage]
Store at -20°C | [References]
1. Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization J. Med. Chem. 52(4),1209-1213(2009). |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|