| Identification | Back Directory | [Name]
Sparstolonin B | [CAS]
1259330-61-4 | [Synonyms]
Sparstolonin B
Sparstolonin B >=98% (HPLC)
3H-Pyrano[3,4,5-kl]xanthen-3-one, 4,10-dihydroxy- | [Molecular Formula]
C15H8O5 | [MDL Number]
MFCD28139298 | [MOL File]
1259330-61-4.mol | [Molecular Weight]
268.22 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO : 10 mg/mL (Need ultrasonic and warming) | [form ]
powder | [color ]
white to beige | [InChI]
1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H | [InChIKey]
DHSASSJDMAHICE-UHFFFAOYSA-N | [SMILES]
OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3 |
| Hazard Information | Back Directory | [Uses]
Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2]. | [Biochem/physiol Actions]
Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury. | [in vivo]
Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice[1]. | Animal Model: | 5-6-week-old male C57Bl/6 mice (body weight 18-20 g)[1] | | Dosage: | 100 μg/mouse | | Administration: | I.p. | | Result: | Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.
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| [IC 50]
TLR2; TLR4; HIV-1 | [References]
[1] Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286(30):26470-26479. DOI:10.1074/jbc.M111.227934
[2] Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25. DOI:10.1186/s12985-015-0339-8
[3] Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11(7):e0159082]. PLoS One. 2014;9(5):e96343. Published 2014 May 1. DOI:10.1371/journal.pone.0096343 |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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