| Identification | Back Directory | [Name]
(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol | [CAS]
1203490-23-6 | [Synonyms]
EPI002
(R)-3-(4-(2-(4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
1,2-Propanediol, 3-[4-[1-[4-[(2S)-3-chloro-2-hydroxypropoxy]phenyl]-1-methylethyl]phenoxy]-, (2R)- | [Molecular Formula]
C21H27ClO5 | [MDL Number]
MFCD30502912 | [MOL File]
1203490-23-6.mol | [Molecular Weight]
394.89 |
| Chemical Properties | Back Directory | [Boiling point ]
601.0±55.0 °C(Predicted) | [density ]
1.228±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (253.24 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.13±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC)[1][2]. | [in vivo]
EPI-002 (100 mg/kg; p.o. twice daily for 28 days) inhibits the VCaP tumor growth in castrated mice[1]. | Animal Model: | Male NOD-SCID mice bearing subcutaneous tumors were castrated | | Dosage: | 100 mg/kg | | Administration: | P.o. twice daily for 28 days | | Result: | Inhibited the growth of castration-resistant prostate cancer (CRPC) xenografts that express AR splice variants[1].
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| [storage]
4°C, protect from light | [References]
[1] Myung JK, et, al. An androgen receptor N-terminal domain antagonist for treating prostate cancer. J Clin Invest. 2013 Jul;123(7):2948-60. DOI:10.1172/JCI66398
[2] Yang YC, et, al. Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2016 Sep 1;22(17):4466-77. DOI:10.1158/1078-0432.CCR-15-2901 |
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| Company Name: |
TaiChem Taizhou Limited
|
| Tel: |
052386810091 |
| Website: |
https://www.chemicalbook.com/supplier/11410902/1.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|