| Identification | Back Directory | [Name]
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide | [CAS]
1206170-62-8 | [Synonyms]
TC Mps1 12
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide | [Molecular Formula]
C17H20N6O | [MOL File]
1206170-62-8.mol | [Molecular Weight]
324.38 |
| Chemical Properties | Back Directory | [Boiling point ]
601.0±55.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
<32.44mg/ml in DMSO; <6.49mg/ml in ethanol | [form ]
Solid | [pka]
16.23±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TC Mps1 12 is a potent and selective Mps1 kinase inhibitor. | [in vivo]
TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss[1].
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg[1].
| Animal Model: | A549 mouse xenograft model[1] | | Dosage: | 25 mg/kg, 50 mg/kg, 100 mg/kg | | Administration: | Oral administration; once daily; for 19 days | | Result: | Inhibited the growth of A549 cells in a dose-dependent manner. |
| Animal Model: | A549 mouse xenograft model (pharmacokinetic )[1] | | Dosage: | 25 mg/kg | | Administration: | Oral administration | | Result: | Cmax = 3542 ng/mL, AUC = 6604 ng h/mL |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|