| Identification | Back Directory | [Name]
NVS-CRF38 | [CAS]
1207258-55-6 | [Synonyms]
NVS-CRF38
Pyrazolo[5,1-b]oxazole, 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethyl- | [Molecular Formula]
C19H21N5O2 | [MDL Number]
MFCD28167820 | [MOL File]
1207258-55-6.mol | [Molecular Weight]
351.4 |
| Hazard Information | Back Directory | [Uses]
NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.
IC50 value:
Target: CRF1 antagonist | [References]
[1] Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3. DOI:10.3109/00498254.2014.907458
[2] Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42(7):1117-24. DOI:10.1124/dmd.113.056408 |
|
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|