| Identification | Back Directory | [Name]
Propargyl-NH-PEG3-C2-NHS ester | [CAS]
1214319-94-4 | [Synonyms]
Propargyl-NH-PEG3-C2-NHS ester | [Molecular Formula]
C16H24N2O7 | [MDL Number]
MFCD20229266 | [MOL File]
1214319-94-4.mol | [Molecular Weight]
356.37 |
| Hazard Information | Back Directory | [Uses]
Propargyl-NH-PEG3-C2-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-NH-PEG3-C2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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