1214323-40-6

75-46-7

4214-79-3

1214323-40-6

GENERAL STEPS: Using the same setup as in Method B [21], potassium hydroxide (2.52 g, 45 mmol, 15 eq.) and water (2.52 g) were added to the reaction vessel and the mixture was stirred until the potassium hydroxide was almost completely dissolved. Subsequently, 5-chloropyridin-2-one (0.354 g, 3 mmol) was added and stirring was continued for 30 minutes. Acetonitrile (10 mL) was added via syringe and the mixture was stirred at room temperature. Trifluoromethane was slowly drummed into the mixture for 2 hours, after which the reaction mixture was continued to be stirred for 1 hour. After completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate. The organic layer was washed with saturated sodium hydroxide solution, separated and concentrated. Purification by silica gel column chromatography using an 80:20 hexane/dichloromethane solvent mixture as eluent to remove impurities resulted in the liquid product 5-chloro-2-(difluoromethoxy)pyridine in 53% yield.