| Identification | More | [Name]
5-Chloro-2-methoxypyridine | [CAS]
13473-01-3 | [Synonyms]
2-METHOXY-5-CHLORO PYRIDINE
5-CHLORO-2-METHOXYPYRIDINE
Pyridine, 5-chloro-2-methoxy- | [EINECS(EC#)]
626-629-6 | [Molecular Formula]
C6H6ClNO | [MDL Number]
MFCD06254388 | [Molecular Weight]
143.57 | [MOL File]
13473-01-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liquid | [Boiling point ]
181-182 °C (lit.) | [density ]
1.193 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.5260(lit.)
| [Fp ]
128 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to lump | [pka]
1.12±0.10(Predicted) | [color ]
White to Almost white | [Specific Gravity]
1.193 | [InChI]
1S/C6H6ClNO/c1-9-6-3-2-5(7)4-8-6/h2-4H,1H3 | [InChIKey]
NPYYXUYLIHZYOU-UHFFFAOYSA-N | [SMILES]
COc1ccc(Cl)cn1 | [CAS DataBase Reference]
13473-01-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liquid | [Uses]
Reactant for:
- Preparation of biaryls via palladium-catalyzed Hiyama cross-coupling with aryltrifluorosilanes
- Suzuki-Miyaura cross-coupling reactions
| [Synthesis]
1. Sodium hydride (60% dispersed in mineral oil, 5.50 g, 115 mmol, 2 eq.) was added in batches to dry methanol (distilled after treatment with magnesium strips, 25 mL) under nitrogen protection. 2. 2,5-Dichloropyridine (10.0 g, 68 mmol) was added to the above solution. 3. The reaction mixture was refluxed for 18 hours. 4. After completion of the reaction, the reaction was cooled to room temperature and treated with an excess of solid potassium bicarbonate. 5. and treated with excess solid potassium bicarbonate.5. The reaction mixture was filtered and the filtrate was concentrated to 50% of the original volume, at which point solids precipitated out of the solution.6. The solids were washed with hexane, and the washings were combined and concentrated to give the oily material.7. 2-methoxy-5-chloropyridine was purified by distillation under reduced pressure (102 °C, 2400 Pascals) to give 6.30 g (65% yield) as a colorless oily material. colorless oil. Mass spectra (chemical ionization, CH4) m/z: 144 (M+, 100), 146 (44), 172 (M+28, 19), 124 (9). | [References]
[1] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 8, p. 1245 - 1249
[2] Patent: US5512575, 1996, A |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
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