| Identification | Back Directory | [Name]
1H-Isoindole-5-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo- | [CAS]
1216805-11-6 | [Synonyms]
1H-Isoindole-5-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo- | [Molecular Formula]
C14H10N2O6 | [MDL Number]
MFCD32063447 | [MOL File]
1216805-11-6.mol | [Molecular Weight]
302.24 |
| Chemical Properties | Back Directory | [Boiling point ]
648.3±50.0 °C(Predicted) | [density ]
1.640±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.29±0.20(Predicted) | [color ]
Pale purple to purple |
| Hazard Information | Back Directory | [Description]
2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid is a thalidomide analog that can be useful in PROTAC research. | [Uses]
Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1]. | [IC 50]
Cereblon | [References]
[1] Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63. DOI:10.1039/c3ob40595h |
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