| Identification | Back Directory | [Name]
MK-3903 | [CAS]
1219737-12-8 | [Synonyms]
MK-3903
MK-3903; MK 3903; MK3903;1219737-12-8
Benzoic acid, 5-[(5-[1,1'-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl- | [Molecular Formula]
C27H19ClN2O3 | [MDL Number]
MFCD31744453 | [MOL File]
1219737-12-8.mol | [Molecular Weight]
454.9 |
| Chemical Properties | Back Directory | [Boiling point ]
712.6±70.0 °C(Predicted) | [density ]
1.349±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);219.83(Max Conc. mM) | [form ]
A solid | [pka]
3.40±0.25(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. | [in vivo]
The pharmacokinetics of MK-3903 (compound 42) in C57BL/6 mice, Sprague to Dawley rats, and beagle dogs are characterized by moderate systemic plasma clearance (5.0 to13 mL/min/kg), a volume of distribution at steady state of 0.6 to 1.1 L/kg, and a terminal halflife of ~2h. Acute oral administration of MK-3903 (3, 10, and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses[1]. | [IC 50]
AMPK: 8 nM (EC50) |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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