| Identification | Back Directory | [Name]
MK-0941 | [CAS]
1137916-97-2 | [Synonyms]
MK-0941
MK-0914
CS-2679
MK-0941;MK0941
MK-0941 mesylate | [Molecular Formula]
C22H28N4O9S2 | [MDL Number]
MFCD30532700 | [MOL File]
1137916-97-2.mol | [Molecular Weight]
556.609 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes[1]. | [References]
[1] Eiki J, et al. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs. Mol Pharmacol. 2011 Dec;80(6):1156-65. DOI:10.1124/mol.111.074401 |
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