| Identification | Back Directory | [Name]
Evogliptin Tartrate | [CAS]
1222102-51-3 | [Synonyms]
DA-1229 tartrate
Evogliptin Tartrate | [Molecular Formula]
C23H32F3N3O9 | [MDL Number]
MFCD32858272 | [MOL File]
1222102-51-3.mol | [Molecular Weight]
551.52 |
| Hazard Information | Back Directory | [Uses]
Evogliptin Tartrate is a useful intermediate used in the preparation of dipeptidyl peptidase-IV inhibitors and derivatives for the treatment of type 2 diabetes. | [in vivo]
Evogliptin tartrate (100, 300 mg/kg; in animal feedings; single daily for 10 weeks) exhibits antidiabetic effects on HFD/STZ mice and improves glucose intolerance and insulin resistance[3]. | Animal Model: | Male ICR mice (four-week-old; HFD/STZ mice model)[3]. | | Dosage: | 100, 300 mg/kg | | Administration: | In animal feedings; single daily for 10 weeks | | Result: | Decreased the blood glucose level from the second weekand persisted through the 10-week treatment, when at 300 mg/kg.
Significantly reduced HbA1c level when dosage at 300 mg/kg.
Significantly decreased 6 h-fasted blood glucose levels in a dose-dependent manner.
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| [IC 50]
DPP-4 | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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