| Hazard Information | Back Directory | [Description]
L 364918 is an oxytocin antagonist; synthetic derivative of L 156373. | [Uses]
L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with Ki values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance[1]. | [IC 50]
V2 Receptor: 2400 nM (Ki); V1 receptor: 1300 nM (Ki); oxytocin: 30 nM (Ki) | [References]
[1] Pettibone DJ, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. DOI:10.1210/endo-125-1-217 |
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