| Identification | Back Directory | [Name]
1H-Indole-2,3-dione, 1-[[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]- | [CAS]
1222834-53-8 | [Synonyms]
ML137
VU0366369 (Synonyms: ML137)
1-(2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)indoline-2,3-dione
1H-Indole-2,3-dione, 1-[[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]- | [Molecular Formula]
C19H14FN3O2 | [MOL File]
1222834-53-8.mol | [Molecular Weight]
335.33 |
| Chemical Properties | Back Directory | [Boiling point ]
545.5±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Slightly Soluble: 0.1-1 mg/ml | [pka]
1.29±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases[1]. | [References]
[1] Bridges TM, et al., Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. DOI:10.1016/j.bmcl.2010.01.109 |
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