| Identification | Back Directory | [Name]
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide | [CAS]
1630936-95-6 | [Synonyms]
ML-396
VU 0422288
ML396 >=98% (HPLC)
VU0422288 (Synonyms: ML396)
N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide | [Molecular Formula]
C17H11Cl2N3O2 | [MDL Number]
MFCD28411626 | [MOL File]
1630936-95-6.mol | [Molecular Weight]
360.19 |
| Chemical Properties | Back Directory | [Melting point ]
154-158°C | [Boiling point ]
422.6±45.0 °C(Predicted) | [density ]
1.445±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
10.42±0.70(Predicted) | [color ]
Light Red to Red |
| Hazard Information | Back Directory | [Uses]
VU 0422288 is a metabotropic glutamate receptor 7 (mGlu7) positive allosteric modulators. | [Biological Activity]
ML396 is a potent positive allosteric modulator or metabotropic glutamate receptors group III (mGlu group III PAM). ML396 was used to study the biology of mGlu7. | [in vivo]
VU0422288 (30 mg/kg; i.p.; once daily for 17 days) rescues synaptic plasticity defects and learning and memory phenotypes, reduces the number of apneas in Mecp2+/- mice, while VU0422288 has no effect in Mecp2+/+animals[2].
VU0422288 (10 mg/kg; i.p.; single dose) exhibis a plasma/brain partitioning coefficient of 1.67 in adult male Sprague-Dawley rats, with predicted unbound brain concentration of about 40 nM[2]. | [IC 50]
mGluR4: 108 nM (EC50); mGluR7: 146 nM (EC50); mGluR8: 128 nM (EC50) | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|