| Identification | Back Directory | [Name]
Benzoic acid, 4-[[[[[2-(2-methyl-1H-imidazol-1-yl)-4-pyridinyl]methyl]amino]carbonyl]amino]-, ethyl ester | [CAS]
1223378-42-4 | [Synonyms]
Nampt-IN-7
Benzoic acid, 4-[[[[[2-(2-methyl-1H-imidazol-1-yl)-4-pyridinyl]methyl]amino]carbonyl]amino]-, ethyl ester | [Molecular Formula]
C20H21N5O3 | [MOL File]
1223378-42-4.mol | [Molecular Weight]
379.41 |
| Hazard Information | Back Directory | [Uses]
Nampt-IN-7 (compound GF8) is a potent NAMPT inhibitor, with an IC50 of 7.31 μM. Nampt-IN-7 also displays cytotoxic activity against human HepG2 hepatocellular carcinoma cell line with an IC50 of 24.28 μM[1]. | [References]
[1] Ozgencil F, et al. Identification of small-molecule urea derivatives as novel NAMPT inhibitors via pharmacophore-based virtual screening. Bioorg Med Chem. 2020 Jan 1;28(1):115217. DOI:10.1016/j.bmc.2019.115217 |
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