| Identification | Back Directory | [Name]
Copper, [[propanedioic acid 1,3-bis[2-methyl-2-[phenyl(thioxo-κS)methyl]hydrazidato-κN1]](2-)]-, (SP-4-2)- | [CAS]
1224195-72-5 | [Synonyms]
Cu(II)-elesclomol
Copper, [[propanedioic acid 1,3-bis[2-methyl-2-[phenyl(thioxo-κS)methyl]hydrazidato-κN1]](2-)]-, (SP-4-2)- | [Molecular Formula]
C19H20CuN4O2S2 | [MOL File]
1224195-72-5.mol | [Molecular Weight]
464.06 |
| Hazard Information | Back Directory | [Uses]
Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity[1]. | [References]
[1] Brian B Hasinoff, et al. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). hem Pharmacol. 2015 Feb 1;93(3):266-76. DOI:10.1016/j.bcp.2014.12.008
[2] Brian B Hasinoff, et al.? Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). hem Pharmacol. 2015 Feb 1;93(3):266-76. DOI:10.1016/j.bcp.2014.12.008 |
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