| Identification | Back Directory | [Name]
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- | [CAS]
1227098-15-8 | [Synonyms]
NF-κB-IN-1
NF-kB-IN-1(AC17)
AC17 NF-κB-IN-1
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- | [Molecular Formula]
C31H30O8 | [MOL File]
1227098-15-8.mol | [Molecular Weight]
530.57 |
| Chemical Properties | Back Directory | [Boiling point ]
732.0±60.0 °C(Predicted) | [density ]
1.233±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.27±0.31(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1]. | [Biological Activity]
NF-κB-IN-1, a 4-arylene curcumin analog, is a potent NF-κB signaling pathway inhibitor. It directly inhibits IKK to block NF-κB activation. It can effectively inhibit the viability of lung cancer cells and attenuate the clonal activity of A549 cells. | [in vitro]
NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI 50 s of 0.72, 0.07, 0.13, and 0.16 μM, respectively. | [target]
| [References]
[1] Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73. DOI:10.1021/jm1004545 |
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