| Chemical Properties | Back Directory | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.78±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. TPN171 is a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use. | [Uses]
TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH)[1]. | [IC 50]
PDE5: 0.62 nM (IC50) | [References]
[1] Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990. DOI:10.1021/acs.jmedchem.9b00123 |
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| Company Name: |
SHENZHEN REISCH BIOTECH CO., LTD
|
| Tel: |
0755-0755-28609002 15112530219 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList231967/0_EN.htm |
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