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122956-68-7

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122956-68-7 Structure

122956-68-7 Structure
IdentificationBack Directory
[Name]

modipafant
[CAS]

122956-68-7
[Synonyms]

UK-74505
Modipefant
rac-Modipafant
ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205)
2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester
4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester
3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
[Molecular Formula]

C34H29ClN6O3
[MDL Number]

MFCD00864793
[MOL File]

122956-68-7.mol
[Molecular Weight]

605.09
Chemical PropertiesBack Directory
[density ]

1.34±0.1 g/cm3 (20 ºC 760 Torr)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

12.14±0.70(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Modipafant is a novel and selective PAF antagonist with potent and prolonged oral activity.
[in vivo]

(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection[3].
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively)[4].
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia[5].

Animal Model:8- to 10-week-old BALB/c mice (DEN-2 strain infected)[3]
Dosage:10 mg/kg
Administration:P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10
Result:Decreased by approximately 50% the lethality associated with DEN-2 infection.
Animal Model:Male BALB/C (8- to 10- week-old) wild-type mice[5]
Dosage:5, 10 and 20 mg/kg
Administration:P.o.
Result:Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

modipafant(122956-68-7)1HNMR
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