| Identification | Back Directory | [Name]
modipafant | [CAS]
122956-68-7 | [Synonyms]
UK-74505
Modipefant
rac-Modipafant
ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205)
2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester
4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester
3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester | [Molecular Formula]
C34H29ClN6O3 | [MDL Number]
MFCD00864793 | [MOL File]
122956-68-7.mol | [Molecular Weight]
605.09 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.14±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Modipafant is a novel and selective PAF antagonist with potent and prolonged oral activity. | [in vivo]
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection[3].
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively)[4].
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia[5]. | Animal Model: | 8- to 10-week-old BALB/c mice (DEN-2 strain infected)[3] | | Dosage: | 10 mg/kg | | Administration: | P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10 | | Result: | Decreased by approximately 50% the lethality associated with DEN-2 infection.
|
| Animal Model: | Male BALB/C (8- to 10- week-old) wild-type mice[5] | | Dosage: | 5, 10 and 20 mg/kg | | Administration: | P.o. | | Result: | Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
|
| [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|