| Identification | Back Directory | [Name]
(Z)-GW 5074 | [CAS]
1233748-60-1 | [Synonyms]
(Z)-GW 5074
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-, (3Z)- | [Molecular Formula]
C15H8Br2INO2 | [MOL File]
1233748-60-1.mol | [Molecular Weight]
520.94 |
| Hazard Information | Back Directory | [Uses]
(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1]. | [IC 50]
c-Raf | [References]
[1] Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30. DOI:10.1038/s41586-019-1722-1 |
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