| Identification | Back Directory | [Name]
(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol | [CAS]
1234563-16-6 | [Synonyms]
AN3365
CS-2419
AN3365HCL
AN 3365;AN-3365
AN3365 HCl salt
Epetraborole HCl
AN3365(GSK2251052)
AN3365 (Epetraborole)
AN3365 (hydrochloride)
GSK2251052 hydrochloride
Epetraborole (hydrochloride)
Epetraborole(GSK2251052) hydrochloride
AN 3365;AN-3365;GSK2251052;GSK 2251052;GSK-2251052
(S)-3-(aMinoMethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol
(S)-3-(aminomethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride
1-Propanol,3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-,hydrochloride(1:1)
3-[[(3S)-3-(Aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol hydrochloride (1:1) | [Molecular Formula]
C11H16BNO4 | [MDL Number]
MFCD30343855 | [MOL File]
1234563-16-6.mol | [Molecular Weight]
237.06 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:200.0(Max Conc. mg/mL);731.21(Max Conc. mM)
Water:28.0(Max Conc. mg/mL);102.37(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research[1][2][3]. | [storage]
Store at -20°C | [References]
[1] Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4. DOI:10.1128/AAC.02580-12
[2] O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. DOI:10.1128/AAC.03774-14
[3] Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52. DOI:10.1111/j.1749-6632.2011.06323.x |
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