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1234703-40-2

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1234703-40-2 Structure

1234703-40-2 Structure
IdentificationBack Directory
[Name]

LY-2608204
[CAS]

1234703-40-2
[Synonyms]

CS-898
LY-2608204
LY-2608024
LY-2608204; LY 2608204
(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]cyclopropanecarboxamide
(1R,2S)-2-cyclohexyl-1-(4-(cyclopropylsulfonyl)phenyl)-N-(5-((2-(pyrrolidin-1-yl)ethyl)thio)thiazol-2-yl)cyclopropanecarboxaMide
Cyclopropanecarboxamide, 2-cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]-, (1R,2S)-
(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]cyclopropanecarboxamide LY 2608204
[Molecular Formula]

C28H37N3O3S3
[MDL Number]

MFCD21609257
[MOL File]

1234703-40-2.mol
[Molecular Weight]

559.81
Chemical PropertiesBack Directory
[density ]

1.35
[storage temp. ]

Store at -20°C
[solubility ]

≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH
[form ]

solid
[pka]

8.17±0.70(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

LY2608204 is an activator of glucokinase (GK; EC50 = 42 nM). It stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 = 579 nM). LY2608204 (30 mg/kg) decreases plasma glucose levels in a dose-dependent manner in fasted rats.
[Uses]

Globalagliatin (LY2608204) is an orally active glucokinase (GK) activator with an EC50 of 42 nM. Globalagliatin also stimulates glucose metabolism in rat insulinoma INS1-E cells with an EC50 of 579 nM. Globalagliatin targets both pancreatic β-cells and hepatocytes. Globalagliatin is promising for research of type 2 diabetes[1][2][3].
[target]

GK
[storage]

Store at -20°C
[References]

[1] kj filipski, bd stevens . glucokinase activators in development .2012 books
Spectrum DetailBack Directory
[Spectrum Detail]

LY-2608204(1234703-40-2)MS
LY-2608204(1234703-40-2)1HNMR
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