| Identification | Back Directory | [Name]
4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro- | [CAS]
1234707-32-4 | [Synonyms]
2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one
4H-3,1-Benzoxazin-4-one, 2-(2-bromophenyl)-5-chloro-
5-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one | [Molecular Formula]
C14H7BrClNO2 | [MDL Number]
MFCD31800416 | [MOL File]
1234707-32-4.mol | [Molecular Weight]
336.57 |
| Hazard Information | Back Directory | [Uses]
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release[1]. | [in vivo]
Neutrophil elastase inhibitor 3 (compound 13, 1 mg/kg of body weight, intravenously) significantly attenuates the increase in myeloperoxidase (MPO) activity and edema in the lung of rats after trauma-hemorrhagic shock[1]. | [References]
[1] Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur J Med Chem. 2010 Jul;45(7):3111-5. DOI:10.1016/j.ejmech.2010.03.046 |
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cjbscvictory
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