| Identification | Back Directory | [Name]
H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH | [CAS]
123562-20-9 | [Synonyms]
ET-2 (HUMAN)
ENDOTHELIN 2
ENDOTHELIN 2 HUMAN
Human endothelin-2
Endothelin-2 (49-69)
ENDOTHELIN-II, HUMAN
ET-2 (HUMAN, PIG, DOG)
EDOTHELIN 2 HUMAN 50 UG
Endothelin 2 (huMan)(9CI)
Endothelin-2 (49-69), human
Endothelin 2, huManEndotheli
ENDOTHELIN-2 (HUMAN, CANINE)
ENDOTHELIN-2 (HUMAN, PIG, DOG)
Endothelin 2 (Canis familiaris)
M.W. 2546.92 C115H160N26O32S4
Endothelin 2, human, ≥97.0% (HPLC)
ET-2 (huMan, canine), VIC (huMan, canine)
Endothelin 1 (swine), 6-L-tryptophan-7-L-leucine-
CSCSSWLDKECVYFCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11)
Endothelin-2 (huMan, canine)
ET-2 (huMan, canine), VIC (huMan, canine)
CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP
H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN
H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP
H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)
CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR- PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)
Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CSCSSWLDKECVYFCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11 | [Molecular Formula]
C115H160N26O32S4 | [MDL Number]
MFCD00133306 | [MOL File]
123562-20-9.mol | [Molecular Weight]
2546.92 |
| Chemical Properties | Back Directory | [density ]
1.286±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble to 1 mg/ml in DMSO | [form ]
powder
| [color ]
white
| [Water Solubility ]
Soluble in water (1 mg/ml) | [Sequence]
Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11) |
| Hazard Information | Back Directory | [Uses]
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. | [in vivo]
Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr[1]. | [storage]
-20°C (desiccate) | [References]
[1] Grimshaw MJ, et al. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol. 2002 Sep;32(9):2393-400. DOI:10.1002/1521-4141(200209)32:93.0.CO;2-4 |
|
|