| Identification | Back Directory | [Name]
740 Y-P | [CAS]
1236188-16-1 | [Synonyms]
740 Y-P
740YPDGFR
PDGFR 740Y-P
740 Y-P, >96%
740 Y-P (PDGFR 740Y-P)
740 Y-P,740YPDGFR,PDGFR 740Y-P, >96%
RQIKIWFQNRRMKWKKSDGGYMDMS (Modifications: Tyr-21 = pTyr)
L-Serine, L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartylglycylglycyl-O-phosphono-L-tyrosyl-L-methionyl-L-α-aspartyl-L-methionyl- | [Molecular Formula]
C141H222N43O39PS3 | [MDL Number]
MFCD07784548 | [MOL File]
1236188-16-1.mol | [Molecular Weight]
3270.7 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [solubility ]
≥163.54 mg/mL in DMSO; insoluble in EtOH; ≥4.87 mg/mL in H2O | [form ]
solid | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{Tyr(PO2)}-Met-Asp-Met-Ser | [InChIKey]
XCGMILZGRGEWHL-QYGSNONCSA-N |
| Hazard Information | Back Directory | [Uses]
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone[1]. | [in vivo]
740 Y-P is not only internalised in living cells but can also interact with p85 in vivo[1].740 Y-P (intraperitoneal?injection; 10 mg/kg; 6 weeks) decreases the degree of ROS levels in Aβ(25-32) treated hippocampal tissues and increases the extent of AKT and PI3K phosphorylation in alzheimer’s disease (AD) rat model[3]. | [IC 50]
PI3K | [storage]
Store at -20°C | [References]
[1] Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. DOI:10.1006/bbrc.1998.9444
[2] Xiaoli Feng, et al. Graphene Oxide Induces p62/SQSTM-dependent Apoptosis Through the Impairment of Autophagic Flux and Lysosomal Dysfunction in PC12 Cells. Acta Biomater.?2018 Nov;81:278-292. DOI:10.1016/j.actbio.2018.09.057
[3] Zhiqing Sun, et al. GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease. J Alzheimers Dis.?2020;76(4):1513-1526. DOI:10.3233/JAD-191032 |
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